Lidocaine-based anesthesia had been recently reported as a successful regimen for induction of anesthesia in elderly population with better hemodynamic profile than opioid-based induction. The investigators hypothesize that lidocaine-based induction of anesthesia would provide superior hemodynamic profile compared to conventional opioid-based induction of anesthesia in emergency laparotomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
149
After preoxygenation with 100% oxygen for 3 minutes, the study drug (lidocaine) will be administered. Patients will receive 1 mg/kg lidocaine of 10 mg/mL lidocaine solution (prepared by diluting 5 mL of lidocaine 20% in saline to a total volume of 10 mL)
After preoxygenation with 100% oxygen for 3 minutes, the study drug (fentanyl) will be administered. Patients will receive 1 mcg/kg fentanyl of 10 mcg/mL fentanyl solution (prepared by diluting 100 mcg fentanyl in saline to a total volume of 10 mL).
After administration of the study drug, all patients will receive 2 mg/kg propofol intravenously
Faculty of Medicine, Cairo University
Cairo, Egypt
Hypotension
Incidence of post-induction hypotension
Time frame: immediately after induction of anesthesia until 20 minutes after induction of anesthesia
Norepinephrine dose
Total norepinephrine dose during the period from induction of anesthesia until 20-minutes after intubation or skin incision
Time frame: from induction of anesthesia until 20 minutes after skin incision
Heart rate
Time frame: every 2 minutes for 20 minutes after induction of anesthesia
Mean Arterial Pressure
Time frame: every 2 minutes for 20 minutes after induction of anesthesia
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After loss of consciousness, 1 mg/kg succinyl choline will be administered over 5 seconds, and tracheal intubation will be done through direct laryngoscopy after 60 seconds.