The Efficacy and Safety of Chiglitazar in Patients with MAFLD-related Cirrhosis

Inclusion Criteria: 1\. Men and women aged between 18 and 75 years (inclusive) who understand and sign informed consent forms; 2. Compensated MAFLD-related cirrhosis diagnosis(meet one of the following conditions): 1. The liver biopsy during the screening period (liver biopsy within 6 months of screening is acceptable) showing cirrhosis with steatohepatitis according to the Non Alcoholic Fatty Liver Disease Clinical Research Network (NASH-CRN) scoring system, and there is no evidence of competitive aetiology. 2. The liver biopsy during the screening period (liver biopsy within 6 months of screening is acceptable) showing cirrhosis with steatosis (no steatohepatitis) according to NASH-CRN scoring system, and there is no evidence of competitive aetiology. There are at least 2 coexisting metabolic comorbidities or history of metabolic comorbidities, including obesity and/or type 2 diabetes mellitus (T2DM). 3. Historical biopsy showed steatohepatitis, and now diagnosed with cirrhosis through non-invasive tests or clinical criteria (see criterion (5)-1)). There is no evidence of competing aetiology. There is at least 1 coexisting or history of metabolic comorbidity. 4. Historical biopsy showed steatosis (no steatohepatitis), and now diagnosed with cirrhosis through non-invasive tests or clinical criteria (see criterion (5)-1)). There is no evidence of competing aetiology. There are at least 2 coexisting metabolic comorbidities or history of metabolic comorbidities, including obesity and/or T2DM. 5. In the absence of biopsy, MAFLD-related cirrhosis is defined based on the following criterias: a. Cirrhosis is defined based on one of the following non-invasive tests(NITS): i: MRE ≥ 5kPa or VCTE-LSM ≥ 20kPa (when the patients with BMI ≥ 28kg/m2 , MRE ≥ 5kPa must also be met); ii:VCTE ≥15 kPa and \<20 kPa and 1 of the following: MRE≥4.45kPa or Agile4≥0.565 or Platelets≤150,000/µL; iii: VCTE \<15 kPa and 2 of the following: MRE≥4.45kPa or Agile4≥0.565 or Platelets≤150,000/µL; b. Current or previous imaging examinations have diagnosed fatty liver or controlled attenuation parameter (CAP)\>288dB/m or magnetic resonance imaging proton density fat fraction (MRI-PDFF)\>5%. c. There is no evidence of competing aetiology; d. There are at least 2 coexisting metabolic comorbidities or history of metabolic comorbidities, including obesity and/or T2DM. 6. If a participant's MAFLD-related cirrhosis diagnosis for eligibility is based on the biopsy screening period , no weight loss of ≥10% should have occurred in the same time period (based on medical history). Exclusion Criteria: 1. Other chronic liver diseases (including but not limited to viral hepatitis, alcoholic liver disease, drug-induced liver injury, autoimmune liver disease, Wilson's disease, hemochromatosis, etc.) 2. There has been a continuous history of heavy drinking for 3 months or more current or rencent 5 years (heavy drinking is defined as \>20 g/day in women and \>30 g/day in men); Or researchers can not reliably quantify alcohol consumption. 3. Hepatic decompensation events (including ascites, esophageal and gastric variceal bleeding, hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis, etc.) or hepatocellular carcinomaor. 4. History of malignant tumors within 5 years (excluding local squamous cell carcinoma of the skin or treated cervical intraepithelial neoplasia)； 5. Combination of autoimmune diseases (including but not limited to systemic lupus erythematosus, multiple sclerosis, Hashimoto's thyroiditis, etc.)； 6. Combined with severe esophageal and gastric varices and/or positive red sign accessed by endoscope； 7. History of liver transplantation or bone marrow transplantationor or listed for liver transplantation; 8. Previous (\<5 years before screening)or planned (during the trial period) treatment for obesity with surgery; 9. Have obesity induced by other endocrinologic disorders (i.e. Cushing Syndrome) genetic diseases; 10. Secondary factors that can cause liver steatosis, such as malnutrition, medication, genetic metabolic diseases, etc. 11. Individuals with the following abnormal indicators: 1. Alanine aminotransferase (ALT)\>5 \* ULN; 2. Aspartate aminotransferase (AST)\>5 \* ULN 3. Direct bilirubin (DBIL)\>1.5 \* ULN 4. Estimated glomerular filtration rate (eGFR)\<60 mL/min/1.73m2 5. Glycated hemoglobin (HbA1c)\>10% 6. MELD score ≥ 12 or Child Pugh score ≥ 8 caused by liver disease 12. History of any type of diabetes than T2DM; 13. Participants receive more than 1 month of treatment with any of the following drugs within 6 months before screening: thiazolidinedione (TZD), glucagon like peptide-1 (GLP-1) receptor agonists, bate lipid-lowing drugs, liver selective thyroxine receptor beta (TSH - β) agonists, obeticolic acid, insulin, berberine, weight-loss drugs, amiodarone, methotrexate, systemic glucocorticoids at \>5 mg/day of prednisone equivalent, tamoxifen, oestrogens at doses higher than those used for hormone replacement or contraception, anabolic steroids except testosterone replacement, valproic acid, and known hepatotoxins; 14. Participants receive the following medications unless they have received a stable dose of at least 1 month prior to screening: beta blockers, thiazide diuretics, statins, niacin, ezetimibe, thyroid hormones, metformin, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium glucose cotransporter (SGLT-2) inhibitors, sulfonylureas, gliptides, alpha glucosidase inhibitors; 15. Participating in clinical trials of other drugs or medical devices within the past 3 months. 16. Participants who demonstrate recent evidence (within 6 months prior to screening) of acute or unstable cardiovascular and cerebrovascular events events (such as hospitalisation for myocardial infarction, stroke, chronic heart failure grade IV (NYHA classification), severe arrhythmia, left ventricular hypertrophy, transient ischemic attack, and/or acute peripheral vascular events); 17. QTc (Fridericia) mean interval that is greater than 500 ms at screening (triplicate electrocardiogram \[ECG\]) or personal or family history of long QT syndrome; 18. Have a history of major surgery or fracture in the past 3 months; 19. Severe osteoporosis or other known bone diseases, or other conditions that may lead to fractures accessed by researchers; 20. History of lower limb or systemic edema; 21. Contraindications for MRI scans, including but not limited to: cerebral aneurysm clips, implanted nerve stimulators, implanted pacemakers or defibrillators, or the presence of artificial heart valves, cochlear implants, potentially ferromagnetic intraocular foreign bodies (such as metal shavings), other implantable medical devices (such as insulin pumps), metal shrapnel or bullets remaining in the body, severe claustrophobia, tattoos (determined by the researcher and radiologist), weight exceeding the carrying capacity of the MRI scanner, etc.; 22. Positive for human immunodeficiency virus (HIV) infection; 23. History of drug use or abuse of drugs within the 12 months prior to screening. 24. patients who have smoked heavily within the past year, with a daily intake of ≥ 30 cigarettes; 25. Pregnant or lactating women, and the woman of childbearing age who are unable or unwilling to use adequate contraception; 26. Researchers believe that patients who are not suitable to participate in this study.