This is a Study Evaluating the Efficacy and Safety of LTG-001 for Acute Pain After Surgical Removal of Impacted Third Molars

Inclusion Criteria: * Subject is male or female aged 18 to 50 years, inclusive, at the time of signing the informed consent * Has a body weight ≥ 45 kg and a BMI ≤ 35 kg/m2. * Subject requires extraction of 2 or more third molars, two of which must be mandibular molars that must be fully or partially bony, or combination of one fully and one partially bony impaction. * Subject must agree to study required use of birth control. * Post-surgical pain must meet protocol requirements. Exclusion Criteria: * Inability to take oral medications * Prior dental surgery within 60 days or other surgical history that could confound surgery or post-operative procedures. * History of impaired hepatic function or heart disease. * Abnormal liver laboratories or other lab abnormality indicative of serious medical condition. * Sensory abnormality that would confound post-surgery pain assessments. * Chronic use of NSAIDs, benzodiazepines, opioid use within the last year, use of medications that prolong QTc intervals, or other dietary and medication restrictions. * A subject with sleep apnea and/or on a home continuous positive airway pressure machine. * Positive drug screen. * Participant is under legal custodianship.