Liver surgeries are high risk surgeries that might result in injuries in kidneys and heart. This study was planned to investigate the frequency of these injuries as well as the risk factors for their devolopment and its effect on patient outcomes.
Hepatic resections are highly invasive major surgical procedures and are associated with higher incidence of end-organ injuries, specifically acute kidney injury (AKI) and perioperative myocardial injury (PMI). This study was designed to determine the incidences of AKI and PMI, and reveal the risk factors for their development and investigate intraoperative labaratory predictors in patients undergoing hepatic resection. We also planned to evaluate the relationship between the occurrence of end-organ injury and length of hospital and intensive care unit (ICU) stay, and 90-day mortality. Patients were identified from a prospectively maintained data file that involves the perioperative data of patients undergoing surgery at Hepatobiliary-Pancreas clinic of Başakşehir Çam\&Sakura City Hospital. All consequtive patients within the study period were evaluated for inclusion. 128 patients were eligible for statistical analysis. This sample size was sufficient to determine the incidence of perioperative organ injury with a margin error of 8.4%. Green formula revealed that the sample size was sufficient for evaluating 9 variables in a regression model.
Study Type
OBSERVATIONAL
Enrollment
128
Başakşehir Çam&Sakura City Hospital
Istanbul, Turkey (Türkiye)
Number of patients sufferd from Acute Kidney injury
at least 0.3mg/dL or 50% increase from baseline creatinine levels within 3 days postoperatively is described as Acute Kidney İnjury. Data will be presented as frequency(percentage) and the margin error of the percentage
Time frame: 3 days postoperatively
Number of patients suffered from Perioperative myocardial injury
At least 14 ng/L increase from baseline high sensitive Troponin T levels within 3 days psotoperatively is described as perioperative myocardial injury. Data will be presented as frequency(percentage) and the margin error of the percentage
Time frame: 3 days postoperatively
Number of patients suffered from perioperative organ injury
Occurence of acute kidney injury or perioperative myocardial injury within 3 days in patients undergoing hepatic resection. Descriptions are clarified in the prior outcomes' description sections. Data will be presented as frequency(percentage) and the margin error of the percentage
Time frame: 3 days postoperatively
Odds Ratios of Risk Factors for the Occurence of perioperartive organ injury
Patients' demographic, medical and intraoperative characteristics will be evaluated in terms of the occurence of perioperative organ injury. Variables with the p value \< 0,05 will be added to the logistic regression model.
Time frame: 3 days postoperatively
Length of intensive care unit stay
Length of intensive care unit stay during postoperative period will be evaluated in patients who did and did not suffer from perioperative organ injury
Time frame: 90 days postoperatively
Length of hospital stay
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Length of hospital stay in the postoperative period, including intensive care will be evaluated in patients who did and did not suffer from perioperative organ injury
Time frame: 90 days postoperatively
90-day mortality
90-day mortality following the surgery will be evaluated in patients who did and did not suffer from perioperative organ injury
Time frame: 90 days postoperatively