Comparative Evaluation of Bromelain-Quercetin Gel With Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing In Stage I /II and Grade B Periodontitis - Randomized Control Clinical Trail

Krishnadevaraya College of Dental Sciences & Hospital30 enrolled

Overview

: Periodontitis is a biofilm associated disease that induces an irreversible inflammatory state that leads to the destruction of the supporting structure of the teeth. Management of periodontal disease is through thorough removal of biofilm which is pivotal for having better oral health. Scaling and root planning (SRP) is fundamental treatment for periodontitis. Years of documented research have established that chlorhexidine digluconate (CHX), gold standard of chemical plaque control agent is safe stable and effective in preventing and controlling plaque formation. Bromelain is an extract derived from Ananas comosus (popularly known as pineapple), contains proteinases that exhibits anti-inflammatory properties, antibacterial effect against periodontopathogens. Bromelain gel has shown to have chemicomechanical method of caries removal. Quercetin present in guava have excellent antibacterial actions against periodontal pathogens, Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi) and Fusobacterium nucleatum (Fn). 2% Quercetin has shown to be advantageous for subgingival application after scaling and rootplaning. Bromelain-Quercetin gel has shown adjunctive effect for treatment in covid-19 patients. As there is less literature in this combination, we intend to study its effects. Individually bromelain and quercetin have been studied for treatment in oral cavity as gel form. This study will be first of its kind to check the efficacy of 2% bromelain-quercetin gel and to compare its effects with 0.2% Chlorhexidine in stage I/II and grade B periodontits.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontal Pocket

Interventions

bromelain-quercetin gelDRUG

bromelain-quercetin gel is prepared from capsules in laboratory

chlorhexidine gelDRUG

chlorhexidine gel is prepared in laboratory

SRPPROCEDURE

Scaling and root planing was done with ultra sonic and hand scaling

Eligibility

Sex: ALLMin age: 30 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patient with have chronic periodontitis in the age group between 30-50 years. * Patients having ≥20 teeth. -.Patients with radiographic evidence of bone loss in atleast two teeth. * Patients who are systematically healthy. * Patients with localized pockets with probing depth of ≤ 5mm. * Patients who are cooperative and able to attend the hospital for regular follow-up. Exclusion Criteria: * Patients who have received any surgical or nonsurgical therapy during past 6months * Pregnant or lactating females. * Use of systemic antibiotics in the past 6 months. * Patient who are not willing to give a written informed consent

Locations (1)

Dr. NALLAGATLA VAMSI VENKATA KRISHNA SAI

Bengaluru, Karnataka, India

Outcomes

Primary Outcomes

PROBING POCKET DEPTH

measured using a UNC-15 probe (university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA

Time frame: 21DAYS

CLINICAL ATTACHMENT LEVEL

(university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA)

Time frame: 21DAYS

Secondary Outcomes

Plaque Index

measured on the tooth surface using a probe

Time frame: 21DAYS

Gingival index

measured on the tooth surface using a probe

Time frame: 21DAYS

Modified Sulcus Bleeding Index

measured on the tooth surface using a probe

Time frame: 21days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.