Safety and Pharmacokinetics Study of HRS-1893 Tablets in Healthy Subjects and Those With Impaired Kidney Function

Inclusion Criteria: 1. Sign the informed consent before the trial, and fully understand the content, process and possible adverse reactions of the trial; 2. Male or female subjects aged 18 to 65 (including 18 and 65); 3. Body mass index (BMI) ranges from 19 kg/m2 to 28 kg/m2 (including 18 and 28); 4. The glomerular filtration rate should meet the following criteria (GFR, mL/min): Subjects with mild renal impairment: 60-89 mL/min; Subjects with moderate renal impairment: 30-59 mL/min. Exclusion Criteria: 1. Suspected allergy to the study drug or any component of the study drug; 2. Patients with cardiogenic shock, severe conduction block, sick sinus syndrome, heart failure, sustained tachyarrhythmia, torsades de pointes (Tdp) or ventricular tachycardia, history of clinically significant T wave changes, myocardial infarction, angina pectoris; 3. People with conditions associated with reduced neuromuscular transmission (myasthenia gravis, Lambert-Eaton syndrome, Duchenne muscular dystrophy); 4. Patients with a history of gastric or intestinal surgery that may affect drug absorption; 5. Participants with renal insufficiency who were judged by the investigator to be ineligible for the study; 6. Patients with large fluctuations or rapid deterioration of renal function within 2 weeks before administration, as judged by the investigator; 7. Subjects receiving renal replacement therapy within 3 months of the screening period or during the expected trial period; 8. Within 3 months before screening, patients with underlying diseases that induced chronic kidney disease and were poorly controlled according to the investigator's evaluation.