Biological Evolution of Whipple's Disease (WHIP)

University Hospital, Brest20 enrolled

Overview

Whipple's disease (WD), a rare systemic infection by Tropheryma whipplei, lacks research on biological abnormalities pre- and post-treatment. This study explores these abnormalities for their diagnostic and monitoring value.

Whipple's disease (WD) is a rare systemic infection caused by \*Tropheryma whipplei\*. Despite advancements in diagnosis through PCR and biopsy, there is limited research comparing biological abnormalities before and after treatment. This study aimed to characterize these abnormalities and evaluate their potential for aiding in diagnosis and monitoring.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Whipple Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with at least one positive PCR test for Whipple's disease and a retained diagnosis at Brest University Hospital between 2010 and 2024 * Major patient Exclusion Criteria: * Minors * No screening test for Whipple's disease * Opposition to participation * Protected patients

Locations (1)

Chu Brest

Brest, France

Outcomes

Primary Outcomes

Biological changes

Biological changes (inflammation, liver function tests, haematology, lymphocyte subpopulations) in patients diagnosed with classic, localised or reactive Whipple's disease

Time frame: 1 day

Data from ClinicalTrials.gov

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