Propolis in Primary Herpetic Gingivostomatitis

Fayoum University60 enrolled

Overview

The purpose of the present study is to investigate the efficacy of 5% propolis gel in the treatment of primary herpetic gingivostomatitis in children and its effect on salivary IFN-γ levels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Herpetic Gingivostomatitis

Interventions

5% propolis gelDIETARY_SUPPLEMENT

5% propolis gel (prepared according to Joshy et al. 2018) Joshy A, Doggalli N, Patil K, Kulkarni PK. To Evaluate the Efficacy of Topical Propolis in the Management of Symptomatic Oral Lichen Planus: A Randomized Controlled Trial. Contemp Clin Dent. 2018 Jan-Mar;9(1):65-71.

Placebo gelOTHER

placebo mucoadhesive gel having the same flavor, consistency, and color as the propolis.

Eligibility

Sex: ALLMin age: 3 YearsMax age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * clinical manifestations suggestive of PHGS * positive culture for HSV-1 Exclusion Criteria: * negative culture for HSV-1 * allergic to honey or its products * patients diagnosed with any systemic diseases, immunosuppressed or immunocompromised patients

Locations (1)

fayoum University

Al Fayyum, Egypt

Outcomes

Primary Outcomes

The severity of oral lesions

mild, moderate, severe

Time frame: one week

Secondary Outcomes

Pain

Visual Analogue Scale

Time frame: one week

measurement of salivary INF-γ level

by ELISA

Time frame: one week

Data from ClinicalTrials.gov

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