NCT06784037 - Optimal Positive End-Expiratory Pressure in Robotic-Assisted Thoracic Surgery Without Capnothorax | Crick | Crick

Optimal Positive End-Expiratory Pressure in Robotic-Assisted Thoracic Surgery Without Capnothorax

N/AEnrolling By InvitationNCT06784037

Hospital Clinic of Barcelona60 enrolled

Overview

The aim of this study is to assess the impact on lung mechanics during robotic lung resection when no capnothorax is used.

Assess the improvement of oxygenation, ventilation and lung mechanics in patients ventilated with individualized PEEP without capnothorax. PEEP requirement and lung mechanics without capnothorax will be compared with a historical cohort population of robotic surgery with capnothorax.

Study Type

OBSERVATIONAL

Enrollment

60

Conditions

Robotic Thoracic Surgery Mechanical Ventilation Positive End Expiratory Pressure (PEEP)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing uniportal robotic lung resection under no capnothorax Exclusion Criteria: * Refusal to participate * Contraindications to recruitment maneuvers

Locations (1)

Hospital Clinic Barcelona

Barcelona, Catalonia, Spain

Outcomes

Primary Outcomes

Respiratory airway pressures

Respiratory airway pressures (peak pressure, plateau pressure and PEEP in cmH2O)

Time frame: During intra-operative mechanical ventilation (4 hours)

Respiratory rate

Respiratory rate (in cycles per minute)

Time frame: During intra-operative mechanical ventilation (4 hours)

Respiratory system compliance

Respiratory pressures measurement will be combined to obtain respiratory system compliance. Respiratory system compliance = (plateau pressure-PEEP) / respiratory tidal volume (expressed in cmH2O/mL)

Time frame: During intra-operative mechanical ventilation (4 hours)

Secondary Outcomes

Arterial blood gas parameters: pO2

pO2 in mmHg in arterial blood gas sample

Time frame: During intra-operative mechanical ventilation (4 hours)

Arterial blood gas parameters: pCO2

pCO2 in mmHg in arterial blood gas sample

Time frame: During intra-operative mechanical ventilation (4 hours)

Arterial blood gas parameters: pH

pH of arterial blood gas samples (no unit can be applied)

Time frame: During intra-operative mechanical ventilation (4 hours)

Arterial blood gas parameters: sodium bicarbonate

Arterial blood sample sodium bicarbonate concentration (in mmol/L)

Time frame: During intra-operative mechanical ventilation (4 hours)

Data from ClinicalTrials.gov

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