Comparison of Inflammatory Factors, Pain Scale, and Postoperative Recovery Quality (QOR - 15) in Patients Undergoing Colorectal Cancer Surgery with Conventional General Anesthesia Techniques Compared to General Anesthesia Combined with Epidural Anesthesia At Prof. Ngoerah Hospital

Phase 4Active Not RecruitingNCT06784258

Udayana University44 enrolled

Overview

Surgery can increase IL-6 cytokines, triggering inflammation and metastasis. The combination of general and epidural anesthesia has the potential to suppress IL-6, improve the tumor microenvironment, provide analgesia, and enhance postoperative recovery. Objectives :To compare the effectiveness of postoperative analgesia quality in colorectal cancer patients receiving general anesthesia combined with epidural anesthesia.

Patients will be divided into 2 groups: Group P (treatment) and Group K (control). Before anesthesia, 2-3 mL of blood will be collected by the researcher from patients in both groups using a red tube. Patients in the control group will undergo conventional general anesthesia. Patients in the treatment group will undergo conventional general anesthesia combined with epidural anesthesia. Patients will be administered 0.25% Bupivacaine local anesthetic incrementally until the desired volume is achieved based on the targeted segmental block height. Six hours postoperatively, 2-3 mL of blood will be collected, VAS (Visual Analog Scale) will be assessed 24 hours postoperatively, and QoR-15 (Quality of Recovery-15) will be evaluated postoperatively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Inflammation Biomarkers Quality of Recovery (QoR-15)

Interventions

General Anesthesia (control group)PROCEDURE

The patient will undergo conventional general anesthesia with a regimen of intravenous fentanyl 1-2 mcg/kg BW, propofol 2-3 ml/kg BW, and muscle relaxants for intubation, such as atracurium 0.5 mg/kg BW or rocuronium 0.6 mg/kg BB. After that the patient will be intubated

General Anesthesia combined with epidural anesthesiaPROCEDURE

The patient will undergo epidural anesthesia first with an epidural catheter inserted through a Tuohy needle and ensuring that the length of the multihole epidural catheter that enters the epidural space is 5-6 cm. After that, the patient underwent conventional general anesthesia with a regimen of intravenous fentanyl 1-2 mcg/kg BW, propofol 2-3 ml/kg BW, and muscle relaxants for intubation, such as atracurium 0.5 mg/kg BW or rocuronium 0.6 mg/ kg BW. After that the patient will be intubated. The patient will be given local anesthesia Bupivacaine 0.25% in increments to the desired volume according to the desired height of the segmental block. Local anesthetic medication will be given intermittently every 2 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 - 65 years * Patients with ASA physical status I - III Exclusion Criteria: * Patients with contraindications to regional anesthesia * Patients with mental disorders or psychiatric disorders * The patient has a history of allergy to the local anesthetic used. * The patient or family refuses to take part in the study * BMI \> 30 Kg/m2

Outcomes

Primary Outcomes

Reduce Interleukin 6 differences

Interleukin 6 will be collected before surgery and 6 hours after surgery by the anesthesiologist in the Operating theatre.

Time frame: before surgery and 6 hours after surgery

Secondary Outcomes

Reduce VAS pain scale

VAS scale will be collected by the anesthesiologist in charge of the patient 24 hours after surgery

Time frame: 24 Hours

Increase Quality of Recovery - 15

QOR-15 score will be collected by the anesthesiologist in charge of the patient 24 hours after surgery