"The Effect of Inhaled Nitroglycerin for COPD Patients

Phase 3RecruitingNCT06785337

Beni-Suef University40 enrolled

Overview

this study aims to investigative the benefits of using nebulized nitroglycerin in improving respiratory functions in patients of late stage COPD

the inhaled nitroglycerin is expected to make vasodilatation of the pulmonary arteries and arterioles which are constricted in late stages of COBD leading to ventilation/perfusion mismatching and further aggravating COPD. it will also help in delivering better antibiotic concentrations to the alveoli which help in better control of infection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

COPD COPD III/IV

Interventions

Inhaled nitroglycerinDRUG

Inhaled nitroglycerin

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient's ≥ 18 years old COPD exacerbation with respiratory failure and Echo evidenced presence of pulmonary hypertension (defined as mean pulmonary artery pressure \> 20 mmHg) Exclusion Criteria: * Profound left ventricular failure, as the decrease in pulmonary vascular resistance results in an increase in left ventricular preload. This may worsen cardiogenic pulmonary edema. * Pregnant female patients * Patient with hypersensitivity to nitroglycerin

Locations (1)

Haram Hospital

Haram, Giza Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

Change in pulmonary functions

Change in pulmonary functions Defined as: * Reduction of PaCO2 in arterial blood gases from admission value. * increase in Pao2 from admission value.

Time frame: 5 days after start of nebulized nitroglycerin

Secondary Outcomes

Number of days on mechanical ventilation

Time frame: 5 days after start of nebulized nitroglycerin

Dose of vasopressor therapy

Time frame: 5 days after start of nebulized nitroglycerin

Reduction of WBC count

Time frame: 10 days after start of nebulized nitroglycerin

Mortality rate

Time frame: 10 days after start of nebulized nitroglycerin

Data from ClinicalTrials.gov

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