Time Course of Endometrium's Gene Expression Profiles Using Endometrial Tissue and Blood Samples

Early Phase 1CompletedNCT06786273

Inti Labs62 enrolled

Overview

This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Fertility

Interventions

Small RNA sequencingGENETIC

The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Regular menstrual cycle of 28-32 days. * Between 25-38 years old. * BMI between 18 to 30. * Endogenous progesterone (P4) level of \< 1 ng/mL prior to exogenous progesterone administration Exclusion Criteria: * Suspected intrauterine abnormality. * Women who are breastfeeding * Have a history of pelvic inflammatory disease, reproductive tract-related diseases, sexually transmitted diseases, systemic diseases or endocrine diseases. * History of major illness. * Use of hormonal contraceptives or intrauterine devices in the past 3 months.

Locations (1)

Lee Women's Hospital

Taichung, Taiwan

Outcomes

Primary Outcomes

miRNA expression profiles

The samples collected would undergo small RNA sequencing in order to investigate the miRNA expression profiles of the patients and differences in expression profiles between the different intervention groups.

Time frame: 1 month

Data from ClinicalTrials.gov

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