The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are: 1. Patients with type 1 diabetes exhibit attenuated vascular function during steady-state exercise 2. Patients with type 1 diabetes have altered autonomic function at rest and during exercise pressor reflex 3. Patients with type 1 diabetes have attenuated muscle sympathetic activity
Elevated blood glucose levels in individuals with type 1 diabetes can result in both microvascular and macrovascular complications. Research conducted by Song et al. revealed that children with type 1 diabetes exhibit abnormal cerebral perfusion. Additionally, autonomic mechanisms are affected in type 1 diabetes, as indicated in an animal study which demonstrated that the exercise pressor reflex is exaggerated in both male and female rats during the early stages of the disease. However, whether this also occurs in human patients with type 1 diabetes remains unknown. Therefore, in this study we are interested in studying the autonomic control of exercise and vascular function in T1DM humans.
Study Type
OBSERVATIONAL
Enrollment
72
University of Texas at Austin
Austin, Texas, United States
Vascular Function
Blood flow (ml/min) will be measured using Doppler ultrasound during steady-state dynamic exercise. Vascular conductance (ml/min/mmHg) will be calculated by dividing blood flow with blood pressure (mmHg). This measure will inform us about the vascular function in type 1 diabetic patients.
Time frame: Blood flow will be measured at baseline for 5 min in supine position. During exercise, blood flow will be measured continuously for the 3 minutes of handgrip exercise.
Autonomic Function
Blood pressure (mmHg) will be measured using Finapres at baseline and during activation of exercise pressor reflex. The exercise reflex will be activated by performing 2 minutes of isometric handgrip exercise at 30% and 40% of the maximal grip strength. This will inform us about the autonomic function in type 1 diabetic patients.
Time frame: Blood presure will be measured at baseline for 10 minutes and continuously during 2 minutes of isometric handgrip.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.