Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases

Inclusion Criteria (general for the study): signed informed consent; subjects aged 18 years and above. Inclusion Criteria (Case): subjects with Marfan syndrome and thoracic aortic aneurysms (in clinical follow-up or with cardiac surgery program); subjects with non-syndromic thoracic aortic aneurysms (in clinical follow-up or with cardiac surgery program); Inclusion Criteria (healthy controls): absence of any aortic/thoracic disease; Exclusion Criteria (all groups): * Presence of any confounding cardiovascular risk factor (hypertension, dyslipidaemia, diabetes, smoking habits) or previous cardiovascular disease * Corticosteroid or Steroids or Fluorochinolones treatment within six months before enrollment Subjects on chronic immunosuppressive therapies such as oral steroids, but also on chronic topical steroids in the area of investigation; * A history of keloid formation (data found in anamnesis and medical records); * Anaesthetic drug allergy (data found in anamnesis and medical records).