Establishment and Validation of Prediction Model of Simultaneous Chemoradiotherapy for Cervical Cancer Organoids

Inclusion Criteria: Able to understand and voluntarily sign written informed consent. 1. Women aged ≥18 years at the time of study entry. 2. Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of 0-2.Life expectancy ≥12 weeks. 3. Histologically confirmed cervical cancer. 4. Histologically-confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma，villous duct carcinoma, invasive mucinous multilayer carcinoma, gastric adenocarcinoma, mesrenal duct carcinoma, clear cell carcinoma, serous carcinoma, endometrioid adenocarcinoma and small cell carcinoma，Intestinal-type adenocarcinoma of the cervix; 5. At least one measurable tumor lesion according to RECIST v1.1 criteria. 6. Available archived tumor tissue samples or recent biopsies. 7. Adequate organ function. 8. For fertile women with negative serum pregnancy and effective contraception within 7 days before administration (until 120 days after the last administration of the study drug and at least 180 days after radiotherapy) Exclusion Criteria: 1. Subject with other active malignancies within 2 years prior enter the study. 2. Subject who cannot receive brachytherapy. 3. Active or prior documented autoimmune disease that may relapse. 4. History of interstitial lung disease or noninfectious pneumonitis. 5. Subject with the clinically significant cardio-cerebrovascular disease. 6. History of severe hypersensitivity reactions to other mAbs. 7. Prior allogeneic stem cell transplantation or organ transplantation. 8. Subjects who require systemic treatment with glucocorticoid (\>10 mg/day of prednisone or equivalent glucocorticoid) or other immunosuppressive agents within 14 days prior enter the study. 9. Receipt of live attenuated vaccines within 30 days prior to the first dose of the study drug. 10. Prior exposure to any experimental antitumor vaccines, or any agent targeting T-cell costimulation or immune checkpoint pathways (eg, anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4, anti-CD137 or anti-OX40 antibody, etc). 11. Any condition that, in the opinion of the Investigator, would interfere with the evaluation of the study drug or interpretation of subject safety or study results. \-