The goal of this observational study is to compare post-induction hypotension treatments with PRAM method in Gynecologic Oncological Cases. The goal of this observational study is to compare post-induction hypotension treatments with PRAM method in Gynecologic Oncological Cases.
Post-induction hypotension is defined as hypotension that occurs within the first 20-30 minutes after general anesthesia induction or during the period between anesthesia induction and surgical incision. The global incidence rates are reported to be approximately 10.3%, with some studies indicating rates as high as 66.96%. Post-induction hypotension is associated with increased postoperative morbidity risks, such as acute kidney injury, transient tubular dysfunction, myocardial injury, and the need for postoperative intensive care. However, hypotension is a modifiable and preventable risk factor; its early detection and appropriate treatment can improve patient outcomes. For this reason, investigators aimed to investigate the repeated dose requirements of alpha-adrenergic drugs, the recurrence of hypotension, and their effects on parameters observed via the MostCare monitor in patients undergoing major gynecologic oncologic surgeries during standard anesthesia induction and maintenance. This investigation focuses on patients experiencing a mean arterial pressure \<65 mmHg or a \>30% reduction in baseline systolic blood pressure within the first 30 minutes after induction or until surgical incision. Additionally, our secondary aim is to examine other parameters that may be associated with post-induction hypotension.
Study Type
OBSERVATIONAL
Enrollment
100
5 milligrams of ephedrine will be applied when post-induction hypotension occured. After 3 doses, dose will be increased or changed to other treatment options.
5 micrograms of ephedrine will be applied when post-induction hypotension occured. After 3 doses, dose will be increased or changed to other treatment options.
Ankara Bilkent Şehir Hastanesi
Ankara, Turkey (Türkiye)
"Is there a difference in the need for repeated doses of treatments to reach the target blood pressure in patients who develop post-induction hypotension?"
When hypotension is occured, researchers applied two treatment (e.g. Ephedrine and Norepinephrine) and assessed how many hypotension episodes occured after treatment
Time frame: First 30 minutes after anesthesia induction or time to skin incision
"Is there a difference in the time to reach the target blood pressure after treatments in patients who develop post-induction hypotension?"
When hypotension is occured, researchers applied two treatment (e.g. Ephedrine and Norepinephrine) and assessed that is there a difference in the time to reach the target blood pressure after treatments
Time frame: First 30 minutes after anesthesia induction or time to skin incision
Systemic vascular resistance (SVR)
To examine the effects of the applied treatments on the systemic vascular resistance from the PRAM method and compare them with each other.
Time frame: First 30 minutes after anesthesia induction or time to skin incision
Arterial Elastance (Ea)
To examine the effects of the applied treatments on the Ea from the PRAM method and compare them with each other.
Time frame: First 30 minutes after anesthesia induction or time to skin incision
Cardiac Output (CO)
To examine the effects of the applied treatments on the CO from the PRAM method and compare them with each other.
Time frame: First 30 minutes after anesthesia induction or time to skin incision
Stroke Volume (SV)
To examine the effects of the applied treatments on the SV from the PRAM method and compare them with each other.
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Time frame: First 30 minutes after anesthesia induction or time to skin incision
Cardiac Cycle Efficiency (CCE)
To examine the effects of the applied treatments on the CCE from the PRAM method and compare them with each other.
Time frame: First 30 minutes after anesthesia induction or time to skin incision