The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group). Participants will: * Be randomly assigned to participate in the mindfulness intervention, or no immediate intervention (waitlist) * Complete paper-and-pencil cognitive testing, surveys, computerized tasks, and neuroimaging measures (EEG and MRI) before and after the intervention Outcomes will be assess at baseline, 2 months, 4 months and 6 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
The Mindfulness Intervention is an adapted form of Mindfulness-based stress reduction (MBSR) training virtual class that meets for 10 weeks. The class involves mindfulness training using awareness and focused attention, group discussion of the experience, and mindful movement. The Mindfulness Intervention also includes daily home practice using mindfulness recordings.
Participants in this arm will first wait 10 weeks and then complete a mindfulness course with outcome measures assessed at baseline, after 10 weeks wait list and then after mindfulness course.
VA Boston Healthcare System - Jamaica Plain Campus
Boston, Massachusetts, United States
RECRUITINGNeuropsychological tests
Paper-and-pencil tests measuring attention, processing speed, and memory.
Time frame: From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)
Performance on computerized tasks
Reaction time and accuracy on computer tasks measuring attention and memory
Time frame: From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)
Resting state and event-related electrophysiology
Electrophysiology measured while at rest and time-locked to performance on a computerized task measuring attention and memory
Time frame: From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)
Brain function and structure
Blood-oxygen-level-dependent (BOLD) for functional magnetic resonance imaging. Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) for structural magnetic resonance imaging.
Time frame: From before the intervention (baseline) to after the intervention (post-intervention 10 weeks))
Survey outcomes
Surveys measuring mood, social isolation, sleep, and quality of life
Time frame: From before the intervention (baseline) to after the intervention (post-intervention 10 weeks))
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