This Study Evaluates the Clinical Effect of Adding Spermidine Gel to Minimally Invasive Non-surgical Periodontal Therapy (MINST) to Improve Periodontal Health.

Luca Ramaglia13 enrolled

Overview

This study investigates the effectiveness of using a spermidine-based gel as an adjunct to minimally invasive non-surgical periodontal therapy (MINST) for treating periodontitis. The primary outcome is to assess whether the addition of spermidine gel reduces pocket depth (PPD) compared to MINST alone. Secondary outcome include evaluating other periodontal parameters like bleeding on probing, FMBS and FMPS and CAL over a 12-month period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Peridontitis

Interventions

spermidine and minimally invasive non surgical tecniquePROCEDURE

minimally non surgical periodontal therapy will be performed with the adjunct of spermidine based gel

peridontal therapy (minimally invasive non surgical tecnique)OTHER

subgingival instrumentation will be performed according to MINST

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: Age 18 years or older. Presence of untreated periodontitis with at least 2 sites showing clinical attachment loss (CAL) \> 2 mm and probing depth (PD) \> 4 mm. Voluntary signing of informed consent. Exclusion Criteria: Presence of systemic diseases (e.g., diabetes mellitus, cardiovascular, renal, hepatic, or pulmonary conditions). Smokers (≥10 cigarettes per day). Pregnancy or breastfeeding. Allergy to any ingredients in the products used in the study. Diseases affecting bone and/or connective tissue metabolism.

Locations (1)

AOU Federico II

Naples, Italy, Italy

Outcomes

Primary Outcomes

Changes in probing depth (PD)

variations in periodontal probing depth between baseline and follow-up

Time frame: From non surgical periodontal therapy to 6 months

Data from ClinicalTrials.gov

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