The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C. The main questions it aims to answer are: * Does Vitamin C supplementation improve the ovarian reserve prediction score? * What medical problems do participants have when taking Vitamin C supplementation? Researchers will compare Vitamin C to a placebo (a look-alike substance that contains no drug) to see if drug Vitamin C works to improve ovarian reserve in women with ovarian aging. Participants will: * Take Vitamin C or a placebo every day for 12 months * Visit the clinic once every 4 weeks for follow-up and drug distribution. * Return the Vitamin C box at each visit. * Report any adverse effects of treatment to the doctor. * Fill out a questionnaire at each visit. * After 6 months and 12 months of intervention, take blood test and ultrasonic examination.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
354
Participants swallow synthetic vitamin C tablets 500mg with water, twice a day.
Participants swallow naturral vitamin C tablets 500mg with water, twice a day.
Participants swallow tablets with the same texture, flavor, and appearance as the experimental group 500mg with water, twice a day.
ovarian reserve prediction score
The ovarian reserve prediction score was calculated using the Ovarian Reserve Prediction Tool, OvaRePred. This tool evaluates the current ovarian reserve status and predicts the future age at which diminished ovarian reserve (DOR) and perimenopause may occur. The score ranges from 0 to 100, with higher scores indicating better ovarian function.
Time frame: 1 year
FSH level
Follicle-stimulating hormone (FSH): Test the blood FSH level of women.
Time frame: 1 year
AMH level
Anti-Müllerian Hormone (AMH) is a hormone produced by the granulosa cells of ovarian follicles. It serves as a key indicator of a woman's ovarian reserve, which refers to the number of viable eggs remaining in the ovaries.
Time frame: 12 months
AFC
Antral Follicle Count (AFC), is a measure used in reproductive medicine to assess a woman's ovarian reserve, that can be seen and counted via transvaginal ultrasound.
Time frame: 12 months
Clinical pregnancy rate
A clinical pregnancy is a pregnancy that is confirmed by ultrasound.
Time frame: 12 months
Time to pregnancy
Time to pregnancy (TTP) refers to the duration it takes for a couple to conceive, starting from the time they begin trying to achieve a pregnancy.
Time frame: 12 months
Livebirth rate
A live birth refers to the delivery of a baby who shows any signs of life after being born, regardless of the pregnancy's duration.
Time frame: 12 months
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