The purpose of this clinical trial is to understand whether oral vitamin C can help delay the aging of middle-aged and elderly individuals, search for sensitive biomarkers of human aging, and provide new paradigms and scientific guidance for aging intervention with small molecule drugs. The main questions it aims to answer are as follows: * Can oral vitamin C effectively improve the aging-related indicators? * What is the safety of participants when taking vitamin C supplements? Researchers will compare vitamin C with a placebo to observe whether vitamin C is effective in intervening in the aging of middle-aged and elderly individuals. Participants need to: * Take 2 tablets (250mg/tablet) of vitamin C or placebo after breakfast and dinner every day for 12 consecutive months; * Go to the designated place for a face-to-face follow-up every 6 months and receive a telephone follow-up every 2 months, and pick up subsequent drugs during the follow-up; * Honestly inform the medication situation during each follow-up; * Report any discomfort or adverse reactions that occur during the treatment process to the researchers; * Fill in a questionnaire about their own health status during each follow-up; * After 6 months and 12 months of intervention, conduct a comprehensive health examination as required, including blood tests and other items.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
400
The first affiliated hospital of Nanchang University
Nanchang, Jiangxi, China
RECRUITINGPeople's Hospital of Quzhou
Quzhou, Zhejiang, China
RECRUITINGPeking University Third Hospital
Beijing, China
ENROLLING_BY_INVITATIONEvaluate the effectiveness of vitamin C in intervening in aging
DNA methylation composite clock
Time frame: 12 months
blood cell transcriptomics
blood cell transcriptomics
Time frame: 12 months
proteomics
proteomics in blood
Time frame: 12 months
metabolomics
metabolomics in blood
Time frame: 12 months
gut microbiome
gut microbiome in fecal sample
Time frame: 12 months
Cognitive function
Trail Making Test
Time frame: 1 year
Physical Fitness Test
The score of Purdue pegboard test, Grip Strength Test,and Single Leg Stand Test with Eyes Closed
Time frame: 1 year
Maximal oxygen consumption
Maximal oxygen consumption
Time frame: 1 year
Motor Function
Hamilton Anxiety Scale
Time frame: 1 year
muscle mass
By means of measurement of lean body mass using dual-energy X-ray absorptiometry (DXA)
Time frame: 1 year
Cardiovascular disease
Standardised composite score (Z score) of systolic blood pressure, LDL cholesterol, and body-mass index (BMI).
Time frame: 1 year
Vitamin C level
Vitamin C level in serum
Time frame: 1 year
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