Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

Calla IVF Center80 enrolled

Overview

This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pregnancy Rate IVF Blastocyst IVF

Interventions

Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succesOTHER

The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female patients aged 20-40 years. * Normal uterine cavity confirmed by hysteroscopy or sonohysterography. * At least three previous failed IVF cycles or a history of recurrent pregnancy loss (RPL). Exclusion Criteria: * uterine abnormalities, * systemic autoimmune diseases, * severe male infertility factors.

Locations (1)

Calla Ivf Center

Oradea, Bihor County, Romania

Outcomes

Primary Outcomes

the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success.

The value of CD56 NK cell and KIR AA in patients undergoing IVF and pregnancy rate

Time frame: 12 months

Data from ClinicalTrials.gov

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