Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus

Sohag University90 enrolled

Overview

This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Lupus Erythematosus Lupus Nephritis

Interventions

systemic immune inflammatory indexDIAGNOSTIC_TEST

Systemic immune inflammatory index (SII) is a combination of three hematological parameters (platelets, neutrophils, and lymphocytes) and it is calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count.

Eligibility

Sex: ALLMin age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * o Older than 16 years * In a patient with SLE, patients who fulfill the criteria of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR). * In patients with LN, patients whose diagnosis is confirmed by kidney biopsy and pathohistological verification (WHO classification, and the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification. Exclusion Criteria: * Patients with other autoimmune rheumatological diseases, lymphoproliferative disorders, malignancies, liver diseases, end-stage kidney disease, diabetic nephropathy, active infections, recent history of blood transfusion and patients with deficiencies in vitamin B12, folate, and iron are excluded from the study.

Locations (1)

Sohag Faculty

Sohag, Sohag Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

association of systemic immune-inflammation index (SII) disease activity in systemic lupus erythematosus

This study aims to investigate if there is an association between the systemic immune-inflammation index (SII) and disease activity in patients with systemic lupus erythematosus using SLEDAI(systemic lupus erythematosus disease activity index) as a valid index to compare results with

Time frame: baseline

association of systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus

This study aims to investigate the association between the systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus

Time frame: baseline

Central Contacts

Shorouk Mohamed abdelmageed, master degree

CONTACT

02 +01099082079 Shrouk011107@med.sohag.edu.eg

Data from ClinicalTrials.gov

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