Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains to be clarified. Moreover, prebiotic fibres, such as galacto-oligosaccharides (GOS) can promote the proliferation of Bifidobacteria. This is why the current study aims to assess the impact of Bifidobacteria consumption on human gut microbiome with or without GOS compared to control product.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
182
48 healthy volunteers will consume Product A twice per day during 28 consecutive days.
48 healthy volunteers will consume Product B twice per day during 28 consecutive days.
48 healthy volunteers will consume Control product twice per day during 28 consecutive days.
CEN
Dijon, France
Biofortis
Paris, France
Biofortis
Saint-Herblain, France
The primary outcome parameter in this study is the change from baseline after 28-days product consumption of the number of distinct Bifidobacterium species.
Time frame: After 28 days of study product consumption
The changes from baseline after 28-days product consumption in detection and quantification of viable bacteria (i.e. with intact cell membrane) for the Bifidobacterium strains.
Time frame: After 28 days of study product consumption
The change from baseline after 28-days product consumption of Bifidobacterium diversity indices.
Time frame: After 28 days of study product consumption
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