Trial of JMKX003142 in Participants With Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Inclusion Criteria: * Able to understand the procedures of this trial and provide written informed consent voluntarily; * Age between 18 to 55 years, male or female; * ADPKD diagnostic criteria were met before randomization; * Rapidly progressive ADPKD criteria were met. Exclusion Criteria: * 12 weeks prior to screening, patients had taken tolvaptan or another ADPKD improvers, or patients who were assessed by the investigator to be likely to use diuretic during the trial period; * Praticipants who are unable to feel thirst, or have difficulty with fluid/food intake; * Patients who have previously received decompression surgery for renal cysts; or who received major surgery within 12 weeks before signing the ICF; * The investigator think that the praticipant is unable to comply with the requirements of the trial or cannot be evaluated by the trial.