The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.
Study Type
OBSERVATIONAL
Enrollment
60
Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire
Istituto Auxologico Italiano IRCCS, Site Piancavallo
Oggebbio, Verbania, Italy
RECRUITINGOrexin A promoter methylation
Percentage of Orexin A promoter methylation
Time frame: Baseline
Orexin B promoter methylation
Percentage of Orexin B promoter methylation
Time frame: Baseline
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