Oral Supplement and Acute Resistance Exercise

Inclusion criteria COPD subjects: Ability to walk, sit down and stand up independently Age 45 - 100 years Willing to lay in bed for 4 hours during study visits Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: FEV1 \< 70% of reference FEV1 Clinically stable condition and not suffering from a respiratory tract infection or exacerbation of their disease (defined as a combination of increased cough, sputum purulence, shortness of breath, systemic symptoms such as fever, and a decrease in FEV1 \> 10% compared with values when clinically stable in the preceding year) at least 4 weeks prior to the first test day Shortness of breath on exertion Willingness and ability to comply with the protocol Inclusion criteria control subjects: Healthy male or female according to the investigator's or appointed staff's judgment Ability to walk, sit down and stand up independently Age 45 - 100 years Willing to lay in bed for 4 hours during long study visits No diagnosis of COPD Willingness and ability to comply with the protocol Exclusion Criteria all subjects: Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (healthy subjects only) Subjects 86 years and older that fail to get physician eligibility confirmation Established diagnosis of Insulin dependent diabetes mellitus Established diagnosis of malignancy History of untreated metabolic diseases including hepatic or renal disorder Presence of acute illness or metabolically unstable chronic illness Presence of fever within the last 3 days Use of short course of oral corticosteroids within 4 weeks preceding study day Dietary or lifestyle characteristics: Use of protein or amino acid containing nutritional supplements within 5 days of first test day Indications related to interaction with study products: Known allergy or sensitivity to milk or milk products Previous injury that could interfere with participation in resistance exercise protocol Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements (Possible) pregnancy Already enrolled in another clinical trial and that clinical trial interferes with participating in this study Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient