Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

Urinary thromboxane B2 level (pg/mg creat)

Urinary thromboxane B2 level (pg/mg creat)

Time frame: 60 minutes after ingestion of 75 grams of glucose, during a single study visit between 14-20 weeks gestational age

Fasting Salicylate level (ug/mL)

Fasting Salicylate level (ug/mL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

1 Hour Salicylate level (ug/mL)

1 Hour Salicylate level (ug/mL) in venous blood

Time frame: 60 minutes after ingestion of 75 grams of glucose during a single study visit between 14-20 weeks gestational age

2 Hour Salicylate level (ug/mL)

2 Hour Salicylate level (ug/mL) in venous blood

Time frame: 120 minutes after ingestion of 75 grams of glucose during a single study visit between 14-20 weeks gestational age

Fasting PFA-100 epinephrine closure time

Fasting PFA-100 epinephrine closure time in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

1 Hour PFA-100 epinephrine closure time

1 Hour PFA-100 epinephrine closure time in venous blood

Time frame: 60 minutes after ingestion of 75 grams of glucose during a single study visit between 14-20 weeks gestational age

2 Hour PFA-100 epinephrine closure time

2 Hour PFA-100 epinephrine closure time in venous blood

Time frame: 120 minutes after ingestion of 75 grams of glucose during a single study visit between 14-20 weeks gestational age

Homeostatic Model Assessment for Insulin Resistance

Approximates insulin resistance.

Time frame: Calculated from fasting insulin and fasting glucose collected at the start of a single study visit between 14-20 weeks gestational age

Fasting Resting Metabolic Rate

Resting metabolic rate describes whole body caloric expenditure, which is assessed using indirect calorimetry

Time frame: Measured at the start of a single study visit between 14-20 weeks gestational age

Fasting Respiratory Quotient

Resting respiratory quotient describes whole body caloric expenditure, which is assessed using indirect calorimetry

Time frame: Measured at the start of a single study visit between 14-20 weeks gestational age

Fasting Carbohydrate Oxidation Rate

Fasting carbohydrate oxidation rate measures whole body carbohydrate oxidation, which is assessed using indirect calorimetry

Time frame: Measured at the start of a single study visit between 14-20 weeks gestational age

Fasting Lipid Oxidation Rate

Fasting lipid oxidation rate measures whole body lipid oxidation, which is assessed using indirect calorimetry

Time frame: Measured at the start of a single study visit between 14-20 weeks gestational age

Fasting Insulin (mIU/mL)

Fasting insulin level (mIU/mL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting glucose (mg/dL)

Fasting glucose level (mg/dL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting lactate (mmol/L)

Fasting lactate level (mmol/L) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting triglycerides (mg/dL)

Fasting triglycerides level (mg/dL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting high density lipoprotein (mg/dL)

Fasting high density lipoprotein level (HDL) (mg/dL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting very low density lipoprotein (mg/dL)

Fasting very low density lipoprotein level (VLDL) (mg/dL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting low density lipoprotein (mg/dL)

Fasting low density lipoprotein level (LDL) (mg/dL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting cholesterol (mg/dL)

Fasting cholesterol level (mg/dL) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age

Fasting free fatty acids (mEq/L)

Fasting free fatty acids (FFA) (mEq/L) in venous blood

Time frame: Fasting, at the beginning of a single study visit between 14-20 weeks gestational age