The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.
The impact of combined follicle-stimulating hormone (FSH) and luteinizing hormone (LH) treatment on ovulation stimulation in older infertile women has garnered significant attention in reproductive medicine. While research indicates improved in vitro fertilization (IVF) pregnancy rates in women aged 35-40 receiving combined FSH and LH therapy compared to FSH alone, the underlying mechanisms and effectiveness remain unclear. This prospective study aims to investigate the effects of combined FSH and LH treatment on cumulus cell energy metabolism in infertile women aged 35-40 undergoing IVF treatment. The research will involve 60 participants divided into two equal groups: one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will collect comprehensive data including baseline characteristics, infertility history, ovarian function parameters, and ovulation stimulation cycle outcomes. Additionally, cumulus cells will be collected from both groups to compare their mitochondrial metabolic function. Through this investigation, we seek to understand whether the combined hormone approach can enhance cumulus cell energy metabolism and improve overall ovulation stimulation outcomes in this specific age group. CopyRetryClaude can make mistakes. Please double-check responses.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
In the study group, participants receive FSH and LH in IVF cycle
In the control group, participants receive FSH alone in IVF cycle
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan
RECRUITINGoxygen consumption rate of mitochodria (%)
to assess mitocondrial function in cumulus cells
Time frame: through study completion, an average of 3 year
Live birth rate (%)
a viable infant after 24 weeks of gestation
Time frame: through study completion, an average of 3 year
Amount of ATP production (moles/min) of mitochodria
to assess mitocondrial function in cumulus cells
Time frame: through study completion, an average of 3 year
Clinical pregnancy rate (%)
the presence of a fetal heartbeat detected via transvaginal sonography at 6-7 weeks of gestation
Time frame: through study completion, an average of 3 year
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