As part of the usual clinical activity of the Emergency and Post-Emergency Psychiatric Department, IV ketamine is used to treat suicidal crises in depressed patients hospitalized as an add-on to the treatment of depression. This infusion can be repeated. Patients are systematically reassessed twice in the month following the last infusion, to ensure that the suicidal crisis is progressing. Psychometric assessments are part of routine care, to ensure systematic evaluation of psychopathology, intensity of depression and suicidality. Therefore existing data were re-used from the medical records of patients who had received ketamine infusions to assess the effect of ketamine on suicidal ideation and behaviour.
Study Type
OBSERVATIONAL
Enrollment
128
University Hospital, Montpellier
Montpellier, France
suicidal ideation at 7 days after IV ketamine administration
evolution of suicidal ideation at 7 days after IV ketamine administration in the context of a suicidal crisis using severity of suicidal ideation according to C-SSRS (COLUMBIA-SUICIDE SEVERITY RATING SCALE) The ideation severity subscale ranges from 1 to 5 (higher score indicating more severe ideation). The ideation intensity subscale includes 5 questions each ranging from 1 to 5 (higher score indication more intense ideation). The suicidal behavior subscale includes 4 yes/no questions. The suicidal behavior lethality subscale inquires about the level of actual or potential medical damage.
Time frame: 7 days
suicidal ideation at 1 month after IV ketamine administration
evolution of suicidal ideation at 7 days after IV ketamine administration in the context of a suicidal crisis using severity of suicidal ideation according to C-SSRS (COLUMBIA-SUICIDE SEVERITY RATING SCALE) The ideation severity subscale ranges from 1 to 5 (higher score indicating more severe ideation). The ideation intensity subscale includes 5 questions each ranging from 1 to 5 (higher score indication more intense ideation). The suicidal behavior subscale includes 4 yes/no questions. The suicidal behavior lethality subscale inquires about the level of actual or potential medical damage.
Time frame: 1 month
Severity of depressive symptomatology at 7 days
change in depressive symptomatology at 1 week using Montgomery-Åsberg Depression Rating Scale (MADRS) The scale consists of 10 items rated from 0 to 6. A score between 0 and 6 indicates euthymia, a score between 7 and 19 mild depression, a score between 20 and 34 moderate depression and a score above 34 severe depression.
Time frame: 7 days
Severity of depressive symptomatology at 1 month
change in depressive symptomatology at 1 week using Montgomery-Åsberg Depression Rating Scale (MADRS) The scale consists of 10 items rated from 0 to 6. A score between 0 and 6 indicates euthymia, a score between 7 and 19 mild depression, a score between 20 and 34 moderate depression and a score above 34 severe depression.
Time frame: 1 month
suicidal ideation at 7 days after IV ketamine
number of hospitalization or ER visit for suicidal ideation
Time frame: 7 days
suicidal behavior at 1 month after IV ketamine
number of suicide attempts (confirmed, aborted, interrupted)
Time frame: 1 month
suicidal behavior at 3 months after IV ketamine
number of suicide attempts (confirmed, aborted, interrupted)
Time frame: 3 months
suicidal ideation at 1 month after IV ketamine
number of hospitalization or ER visit for suicidal ideation
Time frame: 1 month
suicidal ideation at 3 months after IV ketamine
number of hospitalization or ER visit for suicidal ideation
Time frame: 3 months
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