New Approach in the Study of the Autonomic Nervous System Through Cardiac Variability in Sleep Apnea Syndrome.

University Hospital, Lille97 enrolled

Overview

The main objective of this study is to compare the different variations of the cardiac variability index measured thanks to the technique developed by the CIC-IT between subjects with severe SAS and healthy subjects with sleep pathology. In a first step, these two groups will be compared in REM sleep phase because it is the period during which the risk of sleep apnea syndrome is the highest. In a second step, the same methodology will be applied for the other sleep phases and correlations will be established with the other markers of cardiac variability (HRV) already known. This will allow to validate a reliable method of screening for SAS that is more accessible in ambulatory settings by means of a machine learning system based on artificial intelligence

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sleep Apnea

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Group healthy subjects - 1): absence of sleep disorder referenced in the ICSD-3. * Epworth Sleep Scale \< 11 * Pittsburgh Quality Sleep Index \< 6 * Berlin Questionnaire: \< 2 positive categories * STOP BANG \<3 * HADS normal * No RLS * Group 2 (subjects with severe SAS - 2): AHI \> 30/h obstructive Exclusion Criteria: Non-inclusion criteria: * Cardiac rhythm disorder * Neurological or psychiatric pathology impacting on ANS * Control group (healthy subjects - 1) * Complaint of sleep disorder * Known sleep disorder * Experimental group (subjects with severe SAS - 2): o Associated sleep pathology at diagnosis of severe SAS * Administrative reasons: * Unable to receive informed information, * Unable to participate in the entire study * Lack of social security coverage * Refusal to sign consent Exclusion criteria * Control group (healthy subjects - 1): * Sleep pathology detected by polysomnography * Total sleep time less than 4 hours * Recording technically not usable

Outcomes

Primary Outcomes

Ability of the high frequency variability index (HFVI) measured in REM sleep phase to differentiate subjects with severe SAS and healthy subjects with sleep pathology

Time frame: Baseline (The day of the polysomnography )

Secondary Outcomes

Mean value of the IVHF in the other sleep stages (N1, N2 and N3)

Variations of the IVHF between subjects with severe SAS and healthy subjects for the other sleep stages

Time frame: Baseline (The day of the polysomnography )

Mean value of other VFC variables in the different sleep stages (REM, N1, N2 and N3)

Variations of the other markers of cardiac variability between subjects with severe SAS and healthy subjects for all sleep phases

Time frame: Baseline (The day of the polysomnography )

Total score and sub-score of the SCOPA-AUT questionnaire (between 0-69), with the possibility of analysis of the different sub-scores.

Variation of other nervous system components by standardized questionnaire between a group with severe SAS and a group of control subjects

Time frame: Baseline (The day of the polysomnography )

New Approach in the Study of the Autonomic Nervous System Through Cardiac Variability in Sleep Apnea Syndrome.

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts