1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.
This study explored the important role of BMP6/SMAD pathway in myocardial/injury protection by observing the effects of different doses of opioids on myocardial injury indexes hs-cTnI and BMP-6 related indexes in patients undergoing lower extremity fracture surgery, as well as the changes of BMP6 expression in bone marrow tissue of fracture end. The relationship between different doses of opioids and BMP6 and cardiac adverse events provides a theoretical basis for clinical rational drug use.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
160
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
Placebo
Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Serum BMP6
Dose measurement of BMP6 in serum
Time frame: Immediate postoperative measurement
one marrow tissue BMP6
To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow tissue of fracture end
Time frame: Immediate postoperative measurement
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