ApoE Genotyping Analysis in Patients With Suspected Non-haemorrhagic Amyloid Angiopathy

Centre Hospitalier Universitaire de Nīmes100 enrolled

Overview

Ischaemic microangiopathic features have recently been incorporated into the criteria for cerebral amyloid angiopathy (CAA). ApoE genotyping (presence of the E4 allele) is routinely used to help determine the aetiology of a haemorrhagic microangiopathy found on MRI. Chronic ischaemic disease in CAA is characterised by the presence of : * multispot pattern on the FLAIR sequence * severe periventricular FLAIR hypersignals with posterior predominance The main aim of this study was therefore to analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected CAA based on ischaemic MRI involvement with a typical radiological pattern.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Amyloid Angiopathy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ischaemic stroke (from causes other than CAA, as CAA is not a frequent cause of ischaemic stroke) with associated stigmata of microangiopathy on MRI that may suggest associated CAA. * Patients treated at Nîmes University Hospital Exclusion Criteria: * Patient refusing to participate

Locations (1)

CHU de Nîmes

Nîmes, Gard, France

Outcomes

Primary Outcomes

ApoE genotypage

To analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected AAC. Endpoint: presence of the E4 allele (Yes/No).

Time frame: baseline