Effect of Exercise on MiR-126 in Individuals With Prediabetes

Inclusion Criteria: * Individuals who were newly diagnosed with prediabetes according to the Oral Glucose Tolerance Test (OGTT) and/or HbA1C criteria * between the ages of 18-60 * were physically inactive (Level 1 according to the International Physical Activity Questionnaire) * were motivated to exercise * Individuals who had no obstacle to exercise as a result of the evaluation made by a cardiologist (ECG, exercise ECG test, etc.) * and who did not show a change in body weight of more than ±2.5 kg in the last six months were included in the study. Exclusion Criteria: * presence of serious medical conditions (e.g. advanced cancer, major neurological or endocrine disorders, respiratory failure) * current cardiovascular disease, BMI \<19 kg/m² * history of metformin use within the last 6 months * receiving hormone replacement therapy * life expectancy less than one year * HIV positivity * substance use * or orthopedic and cognitive disorders that may prevent exercise