The goal of this clinical trial is to investigate the impact of a walking training intervention program on liver enzymes and selected inflammatory markers in postmenopausal women with obesity. The main question it aims to answer is: Does walking training reduce the risk of liver disease by modulating hepatic-enzymes and selected inflammatory markers? Researchers will compare walking training intervention (designed to the experimental group) to non-training intervention (designed to the control group) to see if the training program works to improve liver health in obese postmenopausal women. Participants in the experimental (training) group will: underwent a moderate intensity intermittent walking training (MIWT) at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session. Participants in control group will : not perform any physical training and maintain their usual daily activities.
Postmenopausal obesity is an important public health problem accompanied by increased systemic inflammation that escalates the risk of liver disease. Exercise improved inflammatory and hepatic function. Moderate-intensity intermittent-walking-training (MIWT) is the most feasible for obese-postmenopausal-women. This study aimed to investigate whether MIWT could reduce the risk by modulating hepatic-enzymes and selected inflammatory markers. Thirty-six sedentary obese postmenopausal women (mean age 55.7±3.5) were randomly divided into two groups: training group (TG, n=18) and control group (CG, n=18). The TG underwent a MIWT at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session. Body composition, hepatic (alanine-transaminase (ALT), aspartate-transaminase (AST), alkaline-phosphatase, gamma-glutamyl-transferase (GGT) and serum-bilirubin\] and inflammatory markers \[C-reactive-protein (CRP), and erythrocyte-sedimentation-rate (ESR)) were evaluated at baseline and after 10-week of protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
36
Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week.
High Institute of Sports and Physical Education of Kef
Boulifa, Kef Governorate, Tunisia
Alanine transaminase
Serum concentrations of alanine-transaminase (ALT) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
Aspartate transaminase
Serum concentrations of aspartate-transaminase (AST),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
Alkaline phosphatase
Serum concentrations of alkaline-phosphatase are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
Gamma glutamyl transferase
Serum concentrations of gamma-glutamyl-transferase (GGT),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention)
Serum bilirubin
Serum concentrations of bilirubin are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
C reactive protein
Serum concentration of C-reactive-protein (CRP) are measured from a blood sample (5 ml).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
Erythrocyte sedimentation rate
Erythrocyte-sedimentation-rate (ESR) are measured from a blood sample (5 ml).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
Body composition
Body composition were determined, with barefoot and lightly dressed subjects, using a stadiometer (Holtain Ltd., UK) and an electronic scale (Tanita BC-533, Tokyo, Japan).
Time frame: At baseline and after ten weeks of the training intervention.
Aerobic capacity
The 6-minute walk test was performed before and after the training intervention as an indicator of exercise capacity.
Time frame: At baseline and after ten weeks of the training intervention.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.