Role of Transposable Elements in Septic Immune Aging

University of California, San Francisco116 enrolled

Overview

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

Study Type

OBSERVATIONAL

Enrollment

116

Conditions

Sepsis Sepsis and Septic Shock Sepsis With Multiple Organ Dysfunction (MOD)Sepsis With Acute Organ Dysfunction Sepsis, Severe Sepsis at Intensive Care Unit Sepsis, Severe Sepsis and Septic Shock

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 or older * Admitted to ICU with sepsis (Sepsis 3 Criteria) * SOFA score of at least 2 at time of enrollment Exclusion Criteria: * Patients on organ transplantation immunosuppression * Patients with preexisting leukopenia * Cancer patients receiving CAR-T therapy * Patients who are under 18 years of age or otherwise deemed pediatric * Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock) * Patients with a chronic hemoglobin below 7.0 * Patients who, prior to their ICU admission, are blood transfusion dependent

Outcomes

Primary Outcomes

Immune Aging

Time frame: 6 weeks

Secondary Outcomes

Mortality (30-day)

Time frame: 30 days

Secondary Infection

Time frame: 30 days

Central Contacts

Alexendar R Perez, M.D., Ph.D

CONTACT

415-476-1000 Alexendar.Perez@ucsf.edu

Matthieu Legrand, M.D., Ph.D