This retrospective cohort study was conducted by reviewing the records of consecutive patients referred to Bu Ali Sina Hospital from 2016 to 2023, who were hospitalized with a diagnosis of ischemic stroke. The records of all patients treated with intravenous alteplase during the above period were extracted, and the relevant characteristics were recorded in a questionnaire. In each year, patients with ischemic stroke who were not treated with alteplase but were hospitalized at the Bu Ali Center were selected in a similar number to patients who received alteplase in the same year, and the relevant information was extracted from their records and recorded in a questionnaire. The incidence of post-stroke seizures and epilepsy was determined in both groups, and the factors associated with their incidence were studied and compared.
Study Type
OBSERVATIONAL
Enrollment
199
Mazandaran University of Medical Sciences
Sari, Mazandaran, Iran
Incidence rate of post-stroke seizure
Incidence rate of post-stroke seizure in patients who received alteplase compared to patients who did not receive alteplase.
Time frame: within 7 days following ischemic stroke onset
Incidence rate of post-stroke epilepsy
Incidence rate of post-stroke epilepsy in patients who received alteplase compared to patients who did not receive alteplase.
Time frame: 1 to 7 years following ischemic stroke onset
Factors related to post-stroke seizure occurrence
Demographic factors are registered in the questionnaire based on the patients' files. The severity of ischemic stroke is determined by the National Institutes of Health Stroke Scale (NIHSS). Brain CT findings including territory of infarct, cortical involvement and hemorrhagic transformation are investigated by reviewing the CT scans and recording the results in the questionnaire. Correlation of each mentioned factor with post-stroke seizure occurrence will be assessed using statistical methods.
Time frame: within 7 days following ischemic stroke onset
Factors related to post-stroke epilepsy occurrence
Demographic factors are registered in the questionnaire based on the patients' files. The severity of ischemic stroke is determined by the National Institutes of Health Stroke Scale (NIHSS). Brain CT findings including territory of infarct, cortical involvement and hemorrhagic transformation are investigated by reviewing the CT scans and recording the results in the questionnaire. Correlation of each mentioned factor with post-stroke epilepsy occurrence will be assessed using statistical methods.
Time frame: 1 to 7 years following ischemic stroke onset
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