A small, pilot proof-of-concept placebo-controlled trial to explore the effects of albumin on diuresis in patients with cirrhosis, ascites and lower extremity edema. We will additionally investigate albumin's effect on preventing neurohumoral activation, and acute kidney injury after diuresis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
20
Albumin 25 gram infusion
100 cc of normal saline
West Haven VA Medical Center
West Haven, Connecticut, United States
RECRUITINGChange in fractional excretion of sodium (FENa)
Change in fractional excretion of sodium (FENa) with administration of albumin vs placebo
Time frame: 6 hours (baseline vs hour 6 after albumin vs placebo administration)
Changes in neuro hormonal markers
Changes in neuro hormonal markers including norepinephrine, renin, aldosterone
Time frame: 6 hours and 24 hours
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