Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients

Inclusion Criteria: 1. Histologically proven rectal adenocarcinoma. 2. Stages cT3 with risk of local recurrence, cT4, or N positive, M0 and for which a multidisciplinary meeting recommend TNT. 3. Resectable tumor, or considered as potentially resectable after CRT. 4. No distant metastases. 5. Patient eligible for surgery 6. World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) performance status 0/1. 7. No heart failure or coronary heart disease symptoms (even controlled). 8. No peripheral neuropathy \> grade 1. 9. No prior radiotherapy of the pelvis for any reason and no previous CT 10. No major comorbidity that may preclude the delivery of treatment 11. Adequate contraception in fertile patients. 12. Adequate hematologic function. 13 Adequate hepatic function. 14\. Signed written informed consent. Exclusion Criteria: 1. Metastatic disease 2. Unresectable rectal cancer, including prostatic involvement or extension to pelvic floor muscles Contraindication to 5-FU, or to oxaliplatin or to irinotecan, including Gilbert disease or genotype UGT1A1 3. Medical history of chronic diarrhea or inflammatory disease of the colon or rectum 4. Medical history of angina pectoris or myocardial infarction 5. Other concomitant cancer. 6. Pregnant or breast-feeding woman. 7. Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol or follow-up schedule.