The goals of this clinical trial are to 1) learn how two different rehabilitation interventions for PD can reduce Freezing of Gait (FOG) in people with Parkinson's disease, as assessed by patients, clinicians, and wearable sensors, and 2) to explore whether two different rehabilitation intervention can reduce FOG and improve daily life mobility in people with FOG sufficiently to justify a clinical trial. Participants will: * Be randomly assigned to one of two intervention groups (turning-focused agility exercise or strength-based exercise) * Have one-on-one training sessions three times per week for 6 weeks * Perform in-lab assessments before beginning and after completing the study intervention * Use wearable mobility sensors during daily life to measure their walking and balance
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Specific participant procedures in experimental and active control interventions are simplified to preserve study blinding.
Specific participant procedures in experimental and active control interventions are simplified to preserve study blinding.
Arizona State University
Tempe, Arizona, United States
RECRUITINGOregon Health and Science University
Portland, Oregon, United States
RECRUITINGUniversity of São Paulo, Bauru Campus
Bauru, São Paulo, Brazil
RECRUITINGPatient- Perceived Freezing of Gait Severity
Change in freezing of gait severity with the intervention (scored in likert scale by the patient; 3 = Much improved, 2 = Somewhat improved, 1 = Minimally improved, 0 = No change, -1 = Minimally worse, -2 = Somewhat worse, -3 = Much worse)
Time frame: From enrollment/randomization through intervention; 8 weeks
Clinician- Perceived Freezing of Gait Severity
Change in freezing of gait severity with the intervention (scored in likert scale by the clinician; 3 = Much improved, 2 = Somewhat improved, 1 = Minimally improved, 0 = No change, -1 = Minimally worse, -2 = Somewhat worse, -3 = Much worse
Time frame: From enrollment/randomization through intervention; 8 weeks
Sensors-based Freezing of gait severity
Freezing of Gait Index calculated during a 360 degrees turning in place from wearable sensors; continuous scale, with a higher positive score meaning a greater level of freezing of gait.
Time frame: From enrollment/randomization through intervention; 8 weeks
Time Spent in FOG during daily life
% time spent FOG compared to walking during daily life calculated from wearable sensors
Time frame: From enrollment/randomization through intervention; 8 weeks
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