The purpose of this study is to investigate the effectiveness of statins in the treatment of moyamoya disease based on multimodal magnetic resonance imaging.
Study Type
OBSERVATIONAL
Enrollment
330
Revascularization/Conservative management
Beijing Tiantan Hospital
Beijing, China, China
RECRUITINGRate of participants experiencing cerebrovascular events (TIA, ischemic stroke, or hemorrhagic stroke)
The occurrence of cerebrovascular events, including TIA, ischemic stroke, or hemorrhagic stroke, will be assessed over an 18-month follow-up period.
Time frame: 18 months during follow-up
Changes in Neurological Function (mRS, NIHSS) at 12 and 18 Months After Treatment
The mRS and NIHSS will be used to assess changes in neurological function at 12 and 18 months after treatment.
Time frame: 12 and 18 months during follow-up
Changes in Cognitive Function (MoCA, MMSE) at 12 and 18 Months After Treatment
The MoCA and MMSE will be used to evaluate changes in cognitive function at 12 and 18 months after treatment.
Time frame: 12 and 18 months during follow-up
Structural Remodeling of the Internal Carotid Artery Terminal and Middle Cerebral Artery Wall at 12 and 18 Months After Treatment
High-resolution magnetic resonance vessel wall imaging will be used to evaluate structural remodeling changes in the internal carotid artery terminal and middle cerebral artery wall at 12 and 18 months after treatment.
Time frame: 12 and 18 months during follow-up
Changes in Cerebral Blood Perfusion at 12 and 18 Months After Treatment
ASL will be used to assess cerebral blood perfusion changes at 12 and 18 months after treatment.
Time frame: 12 and 18 months during follow-up
Rate of New Cerebral Infarcts at 12 and 18 Months After Treatment
The occurrence of new cerebral infarcts at 12 and 18 Months after treatment will be evaluated using MRI.
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Time frame: 12 and 18 months during follow-up
Hemodynamic Changes at the Internal Carotid Artery Terminal at 12 and 18 Months After Treatment
4D-Flow MRI and hemodynamic analysis will be used to evaluate changes in hemodynamics at the internal carotid artery terminal at 12 and 18 months after treatment.
Time frame: 12 and 18 months during follow-up
Changes in Blood Lipid Levels at 12 and 18 Months After Treatment
Blood lipid levels will be measured and compared at 12 and 18 months after treatment.
Time frame: 12 and 18 months during follow-up