The goal of this study was to explore the safety and efficacy of hyperbaric oxygen in the treatment of peripheral neuropathy due to paclitaxel analogues
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
226
Administration of 100% oxygen at a pressure of 2.0ATA once daily for 60-90 minutes for a total of 30-40 times.
Administration of pressurised ice gloves 30 minutes before, during, and 30 minutes after administering paclitaxel chemotherapy drugs.
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
Difference in change in CIPN score due to paclitaxel analogues compared to baseline
Difference in change in CIPN score due to paclitaxel analogues compared to baseline
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
NPS degree
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
EORTC QLQ - CIPN20
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
ENS score
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
neuromyography
Time frame: Baseline, 8 week
life quality
FACT-B Quality of Life Score
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
insomnia score
Insomnia Severity Index (ISI)
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
depression score
Hospital Anxiety and Depression Scale (HADS)
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
Exhaustion score
Brief Fatigue Inventory (BFI)
Time frame: Baseline, 2 week, 4 week, 6 week, 8 week
Side effects of hyperbaric oxygen therapy
Time frame: during the hyperbaric oxygen therapy (up to 2 months)
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