This study was designed to evaluate the safety and efficacy of remote ischemic conditioning (RIC) in patients with aneurysmal subarachnoid hemorrhage (aSAH) following surgical clipping. Aneurysmal subarachnoid hemorrhage is a life-threatening condition that occurs when a cerebral aneurysm ruptures, causing bleeding into the subarachnoid space. Surgical clipping of the aneurysm is a standard procedure used to stop the bleeding and prevent re-rupture, thereby stabilizing the patient's condition. Remote ischemic conditioning (RIC) is a non-invasive treatment that involves using a blood pressure cuff to induce brief, temporary cycles of ischemia and reperfusion in a limb. Research suggests that this process may confer systemic protective effects, potentially improving recovery from brain injury or surgery. Although RIC has shown potential to improve outcomes in patients with other neurological conditions, its effect on patients with aSAH who undergo surgical clipping remains unclear. This study will evaluate whether RIC can reduce complications, improve neurological function, and enhance overall recovery in these patients. The findings will help determine whether RIC should be incorporated into the standard treatment regimen for aSAH.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
Remote ischemic conditioning (RIC) was administered twice daily to the unilateral lower limb using a blood pressure cuff inflated to 200 mmHg for 7 consecutive days post-clipping
Guideline-based therapy
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
RECRUITINGProportion of mRS (0-2)
Modified Rankin Scale, mRS; min:0, max:6; A smaller score indicates a better prognosis.
Time frame: 90±7 days post-enrollment in the study
incidence rate of RIC adverse events
RIC adverse events mainly include: limb pain, skin damage, deep vein thrombosis, transient hypertension, etc.
Time frame: From enrollment to the end of RIC at 1 week
mRS Score as ordinal variable
Modified Rankin Scale, mRS; min:0, max:6; A smaller score indicates a better prognosis.
Time frame: 7±1 days post-enrollment in the study
mRS Score as ordinal variable
Modified Rankin Scale, mRS; min:0, max:6; A smaller score indicates a better prognosis.
Time frame: 30±7 days post-enrollment in the study
incidence rate of aSAH complications
The complications of aneurysmal subarachnoid hemorrhage mainly include cerebral vasospasm, delayed cerebral ischemia, hydrocephalus, rebleeding, etc.
Time frame: From enrollment to 90 days post-enrollment
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