The study is testing a new study medicine called NNC0487-0111 for weight control in Chinese people with Body mass index (BMI) greater than or equal to (\>=) 24 kilogram per square meter (kg/m\^2). The aim of this study is to find out how safe the study medicine is and how it behaves in your body. Participants will either get NNC0487-0111 or placebo. Which treatment participants will get is decided by chance. Oral NNC0487-0111 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. The study will last for about 60 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
29
Participants will be randomized to receive NNC0487-0111 tablet orally at dose levels 1, 2, or 3.
Participants will be randomized to receive a placebo tablet orally matched to NNC0487-0111.
Jinan Central Hospital
Ji'Nan, Shandong, China
Jinan Central Hospital
Jinan, Shandong, China
Number of treatment emergent adverse events (TEAEs)
Number of events
Time frame: From first NNC0487-0111 administration (Day 1) to completion of the end-of-study visit (Day 31)
AUC0-24h,MD; the area under the NNC0487-0111 plasma concentration-time curve from time 0 to 24 hours after last multiple dose
measured in hour\*nanomoles per liter (h\*nmol/L)
Time frame: From pre-dose on Day 10 until Day 11
Cmax,MD; the maximum plasma concentration of NNC0487-0111 after last multiple dose
measured in nanomoles per liter(nmol/L)
Time frame: From pre-dose on Day 10 to completion of the end-of-study visit (Day 31)
tmax,MD; the time of maximum plasma concentration of NNC0487-0111 after last multiple dose
measured in hour (h)
Time frame: From pre-dose on Day 10 to completion of the end-of-study visit (Day 31)
Change in bodyweight
measured in percentage (%)
Time frame: From baseline Day 1 to Day 11
Change in fasting plasma glucose
measured in millimoles per liter (mmol/L)
Time frame: From baseline Day 1 to Day 11
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