This study aims to integrate clinical indicators and features of fundus images, combined with metabolomics, to construct an early warning model for diabetic retinopathy (DR) in type 2 diabetes. By combining clinical indicators with metabolomics, the investigators aim to establish a precise DR typing model based on the age of diabetes onset (early-onset diabetes, late-onset diabetes) and based on the coexistence with two types of diabetic macrovascular complications. A multidisciplinary collaboration will be conducted for comprehensive management of DR to control the progression of moderate-stage DR. Cloud-based patient rooms combined with continuous glucose monitoring (CGM) will further explore the role of integrated diabetes retinopathy ward management models in the management of patients undergoing diabetes retinopathy surgery, pioneering a new model for the management of advanced DR.
Study Type
OBSERVATIONAL
Enrollment
2,920
Performing fundus photography on patients to assess the progression of diabetic retinopathy (DR).
Conduct metabolomics testing at enrollment.
The first hosptial of lanzhou university
Lanzhou, China
RECRUITINGShanghai general hosptial
Shanghai, China
RECRUITINGThe forth people's hosptial of shenyang
Shenyang, China
RECRUITINGFundus examination
Assess the severity of diabetic retinopathy (DR), and group accordingly. The high - risk DR cohort and the early - stage DR cohort have a fundus examination once a year; the mid - stage DR cohort has a fundus examination every six months; the late - stage DR cohort has a fundus examination every three months.
Time frame: Conduct examinations at enrollment and twelve months after enrollment.
Metabolomics analysis
By metabolomics, we aim to establish a precise DR typing model based on the age of diabetes onset (early-onset diabetes, late-onset diabetes) and based on the coexistence with two types of diabetic macrovascular complications so that we can better prevent and treat diabetic retinopathy.
Time frame: at enrollment
Triglycerides
Time frame: Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment.
Glycated Hemoglobin
Time frame: Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment.
Insulin levels
Time frame: Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment.
Total Cholesterol
Time frame: Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment.
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