Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

Le Bonheur Children's Hospital25 enrolled

Overview

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Bronchopulmonary Dysplasia Feeding Intolerance

Interventions

Gastric feedingPROCEDURE

Subjects will be fed through a feeding tube that empties into the stomach.

Transpyloric feedingPROCEDURE

Subjects will be fed through a feeding tube that passes through the stomach and empties directly into the small intestine.

Eligibility

Sex: ALLMin age: 1 MonthMax age: 1 Year

Medical Language ↔ Plain English

Inclusion Criteria: * Patients born \<32 weeks' gestation * Currently admitted to the Le Bonheur NICU * Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA) * Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance. Exclusion Criteria: * Known gastrointestinal anomalies * Unable to tolerate ≥100mL/kg/day enteral feeding * Congenital anomalies likely to alter feeding techniques * Surgical feeding tube in place or expected within the next 8 weeks * Expected to remain hospitalized \<8 weeks

Locations (1)

Le Bonheur Children's Hospital

Memphis, Tennessee, United States

RECRUITING

Outcomes

Primary Outcomes

Respiratory Severity Score (RSS)

RSS (the product of mean airway pressure and oxygen fraction) will be calculated before and after each 2-week intervention block.

Time frame: 8 weeks

Data from ClinicalTrials.gov

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