Hypertonic Saline in Posterior Spinal Fusion

Joseph D. Tobias

Overview

This is a prospective, randomized study in patients greater than or equal to 10 years of age scheduled for an posterior spinal fusion that requires invasive monitoring of arterial blood pressure. Subjects will be randomized to receive either standard of care Normosol-R or buffered 2% hypertonic saline for intraoperative fluid resuscitation. The primary objective of this study is to compare intraoperative changes in acid-base status and electrolytes based on the type of fluid administered intraoperatively. The secondary objective is to compare the volume of fluid required and use of adjunctive volume resuscitation with 5% albumin for intraoperative resuscitation when using standard Normosol-R or a novel buffered 2% saline solution.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Scoliosis Idiopathic Scoliosis;Congenital

Interventions

Normosol-RDRUG

Standard of care isotonic fluid.

buffered 2% hypertonic salineDRUG

A solution containing 2% sodium chloride (NaCl) that is "buffered" by the addition of another salt like sodium acetate.

Eligibility

Sex: ALLMin age: 10 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \> or = 10 years of age * ASA 1-3 * Undergoing a PSF procedure requiring two peripheral intravenous infusions and an arterial cannula Exclusion Criteria: * Arterial cannula is not indicated for the surgical procedure * Two peripheral intravenous cannulas are not required * An invasive arterial cannula cannot be placed

Locations (1)

Nationwide Children's

Columbus, Ohio, United States