Cognitive Effects of Exercise in Parkinson's Disease

N/AEnrolling By InvitationNCT06823921

Sule Tinaz30 enrolled

Overview

This pilot study will evaluate the short-term (3 months) and long-term (6 months) effectiveness of a high-intensity interval training (HIIT) program in improving cognitive function and self-efficacy in individuals with PD.

Participants will be assigned to either the HIIT group, which will engage in 3 classes per week, or a standard-of-care control group, which will include people who will continue their standard care and usual physical activities but do not plan on partaking in additional structured exercise interventions for 3 months (except for physical and occupational therapy if medically necessary). Cognitive functions will be measured using standardized tests (Stroop, Trail Making Test-B (TMT-B), verbal fluency (using letters F-A-S), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)), alongside assessing subjective ratings of daily cognitive function using the Neuro Quality of Life - Cognitive Function (Neuro-QoL CF) survey. Secondary outcomes will include self-efficacy measures, specifically regarding goal achievement, managing emotions and daily activities. We will also aim to obtain brain functional MRI (fMRI) and neuromelanin-sensitive MRI (NM-MRI) data from a subset of participants to measure the brain effects of HIIT as exploratory outcomes.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Parkinson Disease

Interventions

ExerciseOTHER

HIIT will include aerobic, strength, and balance exercises and boxing

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of idiopathic Parkinson's disease * Age 40 year and above * Willingness and ability to participate in HIIT exercise classes Exclusion Criteria: * Non-English speaking * Neuropsychiatric disorder other than Parkinson's disease and comorbid depression and anxiety (e.g., stroke, epilepsy, brain tumor, multiple sclerosis, schizophrenia, bipolar disorder, obsessive compulsive disorder, etc.) * High levels of exercise at baseline (exercising at high intensity at least 3 times per week or moderate intensity at least 5 times per week) * Hoehn \& Yahr disease stage \> 3 (physically not independent)

Locations (1)

Yale University

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

Quality of Life in Neurological Disorders (Neuro-QoL) cognitive function survey

Subjective measures of cognitive functioning in daily life. It captures aspects of cognitive functioning such as attention, memory, and executive function. The average T-score is 50. Higher score indicates better performance.

Time frame: 3 months and 6 months

Secondary Outcomes

Executive function composite T-score

Average T-scores of Trail Making Test-B, Stroop, and F-A-S verbal fluency test that are used to test executive functions. The average T-score is 50. Higher score indicates better performance.

Time frame: 3 months and 6 months

Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) memory domain index score

Examines verbal and visual memory performance and calculates an index score (range: 40-160). Higher score indicates better performance.

Time frame: 3 months and 6 months

Data from ClinicalTrials.gov

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