NCT06826274 - Cervical TsDCS on Stroke Patients | Crick

Overview

The present project aims to evaluate the facilitatory modulation of motor responses of the limb upper limb by tsDCS in patients with arm/hand hyposthenia after cerebral ischemia to verify the possible therapeutic benefits that this type of stimulation can induce in terms of of strength, dexterity and effectiveness in acts of daily living.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

40

Conditions

Functional Recovery Motor Rehabilitation

Interventions

tDCSOTHER

Transcranial direct current stimulation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Group Stroke: Inclusion criteria: 1. age over 18 years; 2. first ischemic/hemorrhagic stroke (within 30 days of onset); 3. mild-to-moderate stroke (NIHSS scale score\<16). 4. residual function of the upper limb, assessed by the following scales: - MRC of the distal muscles of the upper limb: score between 2 and 4; - NHISS (items 5A and 5B): score between 1 and 3; 5. ability to give informed consent and understand instructions. Exclusion criteria: 1. severe spasticity (Ashworth Scale score \> 2); 2. severe aphasia; 3. severe neglect; 4. history of disabling neurological disease; 5. history of epilepsy; 6. significant comorbidities; 7. contraindications to tsDCS. Healthy Group: Inclusion criteria: 1. age over 18 years; 2. equalized in age with the patient group. Exclusion criteria: 1. history of stroke progress; 2. history of severe neurological disease.

Locations (1)

IRCCS San Raffaele Roma

Rome, Rome, Italy

Outcomes

Primary Outcomes

improvement of paretic hand performance

The primary outcome measure is the improvement in hand strength and dexterity in individuals with upper limb motor impairment following cerebral ischemia, after the application of tsDCS at the cervical spinal level during Reaching