The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer are * To evaluate the efficacy of an at-home CORE model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors. * To evaluate the exercise adherence rate among adolescents at risk for heart failure and assess barriers to compliance. * To explore which specific CORE resources are of most value to patients in creating sustainable healthy lifestyle modifications. * Hypothesis: Pediatric cancer survivors who implement exercise and dietary recommendations will demonstrate improvement in cardiovascular fitness and general wellness. A multidisciplinary team approach can facilitate adherence to a moderately rigorous exercise prescription, and thus enhance the health benefits of a CORE program at CHLA. Participants will undergo cardiovascular studies and a quality-of-life survey prior to exercise intervention, and at the end of the 6-month study period.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Least 60 minutes of physical activity each day including vigorous-intensity and strengthening activities at least 3 days per week
Children's Hospital Los Angeles
Los Angeles, California, United States
RECRUITINGChange in cardiovascular fitness after completion of a 6-month exercise intervention.
Peak VO2% (exercise capacity) as measured by cardiopulmonary exercise testing.
Time frame: Baseline to 6 months
Change in cardiovascular fitness after completion of a 6-month exercise intervention.
Ve/VCO2 slope (predictor of cardiac mortality) as measured by cardiopulmonary exercise testing.
Time frame: Baseline to 6 months
Change in cardiovascular fitness after completion of a 6-month exercise intervention.
Chronotropic response (heart rate response to exercise) as measured by cardiopulmonary exercise testing.
Time frame: Baseline to 6 months
Change in cardiovascular fitness after completion of a 6-month exercise intervention.
Blood pressure response to exercise as measured by cardiopulmonary exercise testing.
Time frame: Baseline to 6 months
Change in cardiac function after completion of a 6-month exercise intervention.
Cardiac function will be assessed via echocardiogram.
Time frame: Baseline to 6 months
Change in cardiac rhythm after completion of a 6-month exercise intervention.
Cardiac rhythm will be assessed via EKG.
Time frame: Baseline to 6 months
Change in cardiac stress after completion of a 6-month exercise intervention.
Cardiac stress will be assessed via NT-proBNP level.
Time frame: Baseline to 6 months
Average change in triglyceride level as measured from baseline to 6 months.
Triglyceride (mg/dL) will be measured.
Time frame: Baseline to 6 months
Average change in total cholesterol level as measured from baseline to 6 months.
Total cholesterol (mg/dL) will be measured.
Time frame: Baseline to 6 months
Average change in high density lipoprotein level as measured from baseline to 6 months.
High density lipoprotein (HDL) (mg/dL) will be measured.
Time frame: Baseline to 6 months
Average change in low density lipoprotein as measured from baseline to 6 months.
Low density lipoprotein (LDL) (mg/dL) will be measured.
Time frame: Baseline to 6 months
Average change in very low density lipoprotein as measured from baseline to 6 months.
Very low density lipoprotein (VLDL) (mg/dL) will be measured.
Time frame: Baseline to 6 months
Average change in reported quality of life from baseline to 6 months
PedsQL(TM) Measurement Model will be used, which assesses physical, emotional, social, school functioning domains.
Time frame: Baseline to 6 months
Percent of participants with improvement in healthy lifestyle habits from baseline to 6 months
Lifestyle habits will be assessed via exercise and dietary surveys completed by each participant.
Time frame: Baseline to 6 months
Average change in activity level from baseline to 6 months
Activity levels will be assessed via exercise surveys as well as continuous FitBit(TM) activity data which will include weekly number of steps, average calorie burn, days of exercise, minute in activity, and average sleep time.
Time frame: Baseline to 6 months
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