Identification of Microplastics in Liver, Stomach, Blood, and Feces of Obese Patients and Their Association Analysis with Macrogenomics and Metabolomics.

N/AActive Not RecruitingNCT06826586

First Affiliated Hospital of Chongqing Medical University20 enrolled

Overview

The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the association between obesity and visceral microplastics, and to investigate the effects of microplastics on the visceral microbiota and metabolic profiles of obese patients by combining the macro-genomic and metabolomics approaches.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity and Overweight

Interventions

Measuring the microplasticsDIAGNOSTIC_TEST

Measuring the type, nature, and abundance of microplastics in stomach, liver, feces, and blood

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years old; * BMI ≧30; * proposed to undergo bariatric surgery and need to remove part of the liver tissue for fatty liver test; * complete clinical data and basic information; * willing to participate in the study and sign the informed consent form. Exclusion Criteria: * Receive chemotherapy, radiotherapy, immunotherapy; * have other history of digestive diseases; * combined with malignant tumors; * have serious cardiorespiratory insufficiency and other systemic diseases that affect the choice of treatment plan; * not willing to participate in this study.

Outcomes

Primary Outcomes

Differences in microbial communities

Differences in different microbial communities in the stomach, liver, feces, and blood of obese patients

Time frame: From the diagnosis of obesity, through study completion, an average of 1 year.